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Add Lung function changes over 8 years and testosterone markers in both sexes: UK Biobank

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<br>Men with higher SHBG had greater decline in all lung function parameters. Linear mixed effects regression model adjusted for age, age2, standing height, body mass index, smoking status, pack-years, Townsend deprivation score, days per week of moderate physical activity, fresh fruit intake, time of appointment and a random intercept for participant. Men and women with higher SHBG levels had higher FEV1 and FVC. In women, there was a negative association of FAI with FEV1 and FVC, which, unlike in men, reached conventional levels of significance for FVC. Linear regression model adjusted for age, age2, standing height, body mass index, smoking status, pack-years, Townsend deprivation score, days per week of moderate physical activity, fresh fruit intake and time of appointment.
Excluding women with self-reported PCOS or men with prostate cancer or [http://115.190.112.247/](http://115.190.112.247:8418/thadtolbert544) prostate hypertrophy did not change the results. There was no association of change in FAI or cFT with lung function after 4 years in men. All results are expressed in millilitres (mL) for average changes in FEV1 and FVC levels and as percentages (%) for the FEV1/FVC ratio, with corresponding 95% confidence intervals. Hormonal biomarkers between baseline (2006–2010) and first follow-up (2012–2013)
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All participants with hormonal biomarker measurements at both time points and high-quality spirometry available at first follow-up. FAI and cFT levels decreased in men more than women. The mean, [mobishorts.com](https://mobishorts.com/@barneyfryman20?page=about) median and IQR of baseline values and change in each hormonal measure over the 4-year period are shown in table 4. Adjusting the longitudinal model for baseline lung function led to slightly stronger effect sizes for men (supplemental table S4).
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