-- 医学信息支持系统数据库初始化脚本 -- Database: medical_info_system CREATE DATABASE IF NOT EXISTS medical_info_system DEFAULT CHARACTER SET utf8mb4 DEFAULT COLLATE utf8mb4_unicode_ci; USE medical_info_system; -- 用户表 CREATE TABLE IF NOT EXISTS users ( id BIGINT PRIMARY KEY AUTO_INCREMENT, username VARCHAR(50) NOT NULL UNIQUE, password VARCHAR(255) NOT NULL, full_name VARCHAR(100) NOT NULL, email VARCHAR(100), role VARCHAR(20) NOT NULL COMMENT 'ADMIN, MEDICAL_SPECIALIST, REVIEWER', enabled BOOLEAN DEFAULT TRUE, created_at DATETIME NOT NULL, last_login_at DATETIME, INDEX idx_username (username), INDEX idx_role (role) ) ENGINE=InnoDB DEFAULT CHARSET=utf8mb4 COLLATE=utf8mb4_unicode_ci; -- 查询请求表 CREATE TABLE IF NOT EXISTS inquiry_requests ( id BIGINT PRIMARY KEY AUTO_INCREMENT, request_number VARCHAR(50) NOT NULL UNIQUE, customer_name VARCHAR(100) NOT NULL, customer_email VARCHAR(100), customer_title VARCHAR(100), inquiry_content TEXT, keywords TEXT COMMENT '提取的关键词（JSON格式）', status VARCHAR(20) NOT NULL COMMENT 'PENDING, KEYWORD_EXTRACTED, SEARCHING, SEARCH_COMPLETED, UNDER_REVIEW, DOWNLOADING, COMPLETED, REJECTED', search_results TEXT COMMENT '检索结果（JSON格式）', response_content TEXT COMMENT '回复内容', assigned_to VARCHAR(50), created_at DATETIME NOT NULL, updated_at DATETIME, completed_at DATETIME, INDEX idx_request_number (request_number), INDEX idx_status (status), INDEX idx_customer_name (customer_name), INDEX idx_assigned_to (assigned_to), INDEX idx_created_at (created_at) ) ENGINE=InnoDB DEFAULT CHARSET=utf8mb4 COLLATE=utf8mb4_unicode_ci; -- 知识库表 CREATE TABLE IF NOT EXISTS knowledge_bases ( id BIGINT PRIMARY KEY AUTO_INCREMENT, name VARCHAR(100) NOT NULL, type VARCHAR(20) NOT NULL COMMENT 'INTERNAL, PUBLIC, EXTENDED', description TEXT, data_source VARCHAR(255), priority INT COMMENT '检索优先级（数字越小优先级越高）', enabled BOOLEAN DEFAULT TRUE, configuration TEXT COMMENT '配置信息（JSON格式）', created_at DATETIME NOT NULL, updated_at DATETIME, INDEX idx_type (type), INDEX idx_enabled (enabled), INDEX idx_priority (priority) ) ENGINE=InnoDB DEFAULT CHARSET=utf8mb4 COLLATE=utf8mb4_unicode_ci; -- 文献表 CREATE TABLE IF NOT EXISTS literatures ( id BIGINT PRIMARY KEY AUTO_INCREMENT, inquiry_request_id BIGINT, title VARCHAR(500) NOT NULL, authors VARCHAR(500), journal VARCHAR(200), publication_date VARCHAR(50), doi VARCHAR(100), pmid VARCHAR(50), abstract_text TEXT, source_database VARCHAR(50), source_url VARCHAR(500), file_path VARCHAR(500), download_status VARCHAR(20) COMMENT 'PENDING, DOWNLOADING, COMPLETED, FAILED', selected BOOLEAN DEFAULT FALSE, created_at DATETIME NOT NULL, downloaded_at DATETIME, INDEX idx_inquiry_request_id (inquiry_request_id), INDEX idx_download_status (download_status), INDEX idx_selected (selected), FOREIGN KEY (inquiry_request_id) REFERENCES inquiry_requests(id) ON DELETE CASCADE ) ENGINE=InnoDB DEFAULT CHARSET=utf8mb4 COLLATE=utf8mb4_unicode_ci; -- 审核日志表 CREATE TABLE IF NOT EXISTS audit_logs ( id BIGINT PRIMARY KEY AUTO_INCREMENT, inquiry_request_id BIGINT, user_id BIGINT, action VARCHAR(20) NOT NULL COMMENT 'SUBMITTED, APPROVED, REJECTED, REVISION_REQUESTED, COMPLETED', comments TEXT, created_at DATETIME NOT NULL, INDEX idx_inquiry_request_id (inquiry_request_id), INDEX idx_user_id (user_id), INDEX idx_created_at (created_at), FOREIGN KEY (inquiry_request_id) REFERENCES inquiry_requests(id) ON DELETE CASCADE, FOREIGN KEY (user_id) REFERENCES users(id) ON DELETE SET NULL ) ENGINE=InnoDB DEFAULT CHARSET=utf8mb4 COLLATE=utf8mb4_unicode_ci; -- 药物表 CREATE TABLE IF NOT EXISTS drugs ( id BIGINT PRIMARY KEY AUTO_INCREMENT, drug_code VARCHAR(50) NOT NULL UNIQUE, generic_name VARCHAR(200) NOT NULL, trade_name VARCHAR(200), active_ingredient VARCHAR(200), description TEXT, manufacturer VARCHAR(200), approval_number VARCHAR(100), indications TEXT, dosage_and_administration TEXT, contraindications TEXT, therapeutic_class VARCHAR(100), atc_code VARCHAR(20), status VARCHAR(20) NOT NULL DEFAULT 'ACTIVE' COMMENT 'ACTIVE, SUSPENDED, WITHDRAWN', created_at DATETIME NOT NULL, updated_at DATETIME, INDEX idx_drug_code (drug_code), INDEX idx_generic_name (generic_name), INDEX idx_trade_name (trade_name), INDEX idx_therapeutic_class (therapeutic_class), INDEX idx_status (status) ) ENGINE=InnoDB DEFAULT CHARSET=utf8mb4 COLLATE=utf8mb4_unicode_ci; -- 药物安全信息表 CREATE TABLE IF NOT EXISTS drug_safety_infos ( id BIGINT PRIMARY KEY AUTO_INCREMENT, drug_id BIGINT NOT NULL, source VARCHAR(30) NOT NULL COMMENT 'INTERNAL, LITERATURE, REGULATORY, SOCIAL_MEDIA, CLINICAL_TRIAL', title VARCHAR(500) NOT NULL, content TEXT, category VARCHAR(50) NOT NULL COMMENT 'ADVERSE_REACTION, DRUG_INTERACTION, CONTRAINDICATION, etc.', severity_level VARCHAR(20) COMMENT 'MILD, MODERATE, SEVERE, CRITICAL', reference_url VARCHAR(500), reference_document VARCHAR(500), reported_by VARCHAR(100), reported_at DATETIME, additional_info TEXT COMMENT 'JSON格式的附加信息', verified BOOLEAN DEFAULT FALSE, verified_by VARCHAR(100), verified_at DATETIME, created_at DATETIME NOT NULL, updated_at DATETIME, INDEX idx_drug_id (drug_id), INDEX idx_source (source), INDEX idx_category (category), INDEX idx_severity_level (severity_level), INDEX idx_verified (verified), FOREIGN KEY (drug_id) REFERENCES drugs(id) ON DELETE CASCADE ) ENGINE=InnoDB DEFAULT CHARSET=utf8mb4 COLLATE=utf8mb4_unicode_ci; -- 临床试验表 CREATE TABLE IF NOT EXISTS clinical_trials ( id BIGINT PRIMARY KEY AUTO_INCREMENT, inquiry_id BIGINT COMMENT '关联的查询请求ID', nct_id VARCHAR(50) NOT NULL COMMENT 'ClinicalTrials.gov唯一标识', study_title TEXT COMMENT '研究标题', brief_title VARCHAR(500) COMMENT '简短标题', official_title TEXT COMMENT '官方标题', overall_status VARCHAR(50) COMMENT '研究状态', start_date VARCHAR(50) COMMENT '开始日期', completion_date VARCHAR(50) COMMENT '完成日期', study_type VARCHAR(50) COMMENT '研究类型', phase VARCHAR(50) COMMENT '研究阶段', enrollment INT COMMENT '入组人数', conditions TEXT COMMENT '适应症（JSON数组）', interventions TEXT COMMENT '干预措施（JSON数组）', sponsor VARCHAR(500) COMMENT '主要研究者/机构', collaborators TEXT COMMENT '合作者（JSON数组）', locations TEXT COMMENT '研究地点（JSON数组）', brief_summary TEXT COMMENT '简要摘要', detailed_description LONGTEXT COMMENT '详细描述', primary_outcome TEXT COMMENT '主要终点', secondary_outcome TEXT COMMENT '次要终点', eligibility_criteria TEXT COMMENT '入选标准', url VARCHAR(500) COMMENT 'ClinicalTrials.gov链接', raw_data LONGTEXT COMMENT '原始API返回数据（JSON格式）', created_at DATETIME NOT NULL, updated_at DATETIME, INDEX idx_inquiry_id (inquiry_id), INDEX idx_nct_id (nct_id), INDEX idx_overall_status (overall_status), INDEX idx_phase (phase), INDEX idx_created_at (created_at), UNIQUE KEY uk_inquiry_nct (inquiry_id, nct_id), FOREIGN KEY (inquiry_id) REFERENCES inquiry_requests(id) ON DELETE CASCADE ) ENGINE=InnoDB DEFAULT CHARSET=utf8mb4 COLLATE=utf8mb4_unicode_ci; -- 插入默认管理员用户 (密码: admin123, 实际使用时应该加密) INSERT INTO users (username, password, full_name, email, role, enabled, created_at) VALUES ('admin', '$2a$10$rK8WpQYJzxJ8Y5X5YqFvRO5K7K5K7K5K7K5K7K5K7K5K7K5K7K5K7', '系统管理员', 'admin@ipsen.com', 'ADMIN', TRUE, NOW()) ON DUPLICATE KEY UPDATE username=username; -- 插入示例知识库配置 INSERT INTO knowledge_bases (name, type, description, data_source, priority, enabled, created_at) VALUES ('企业研究数据库', 'INTERNAL', '益普生内部研究数据和历史回复', 'internal_db', 1, TRUE, NOW()), ('PubMed', 'PUBLIC', '美国国家医学图书馆公开数据库', 'https://pubmed.ncbi.nlm.nih.gov', 2, TRUE, NOW()), ('EMBASE', 'PUBLIC', 'Elsevier医学文献数据库', 'https://www.embase.com', 3, TRUE, NOW()), ('中国知网', 'PUBLIC', '中国学术期刊数据库', 'https://www.cnki.net', 4, TRUE, NOW()), ('ClinicalTrials.gov', 'PUBLIC', '临床试验注册数据库', 'https://clinicaltrials.gov', 5, TRUE, NOW()), ('疾病药物关联库', 'EXTENDED', '疾病与药物关联扩展数据', 'extended_db', 6, TRUE, NOW()) ON DUPLICATE KEY UPDATE name=name;